6-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells

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6-shogaol, a neuroactive compound of ginger (jahe gajah) induced neuritogenic activity via NGF responsive pathways in PC-12 cells

BACKGROUND Ginger is a popular spice and food preservative. The rhizomes of the common ginger have been used as traditional medicine to treat various ailments. 6-Shogaol, a pungent compound isolated from the rhizomes of jahe gajah (Zingiber officinale var officinale) has shown numerous pharmacological activities, including neuroprotective and anti-neuroinflammatory activities. The aim of this s...

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The neuritogenic and neuroprotective potential of senegenin against Aβ-induced neurotoxicity in PC 12 cells

BACKGROUND Improved therapeutics aimed at ameliorating the devastating effects of neurodegenerative diseases, such as Alzheimer's disease (AD), are pertinent to help attenuate their growing prevalence worldwide. One promising avenue for such therapeutics lies in botanical medicines that have been efficaciously employed in the likes of traditional medicine doctrines for millennium. Integral to t...

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Protective effect of adult olfactory ensheathing cells against 6-OHDA toxicity in PC-12 cells

Olfactory ensheathing cells (OEC) have been successfully used to stimulate the growth of injured fibers and to promote functional recovery within the injured adult CNS. These cells exhibit functional properties, which are known to be involved in axonal elongation. OEC express high level of growth factors including NGF, GDNF, BDNF and NT-3, which are known to play an important role in nerve rege...

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Protective effect of adult olfactory ensheathing cells against 6-OHDA toxicity in PC-12 cells

Olfactory ensheathing cells (OEC) have been successfully used to stimulate the growth of injured fibers and to promote functional recovery within the injured adult CNS. These cells exhibit functional properties, which are known to be involved in axonal elongation. OEC express high level of growth factors including NGF, GDNF, BDNF and NT-3, which are known to play an important role in nerve rege...

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6-shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice.

The rhizome of ginger (Zingiber officinale Roscoe) is known to have several bioactive compounds including gingerols and shogaols which possess beneficial health properties such as anti-inflammatory and chemopreventive effects. Based on recent observations that 6-shogaol may have more potent bioactivity than 6-gingerol, we obtained a 6-shogaol-rich extract from ginger and examined its effects on...

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ژورنال

عنوان ژورنال: BMC Complementary and Alternative Medicine

سال: 2017

ISSN: 1472-6882

DOI: 10.1186/s12906-017-1837-6